Dietary Supplementation of Bile Acids in Tongue Sole (Cynoglossus semilaevis): A Promising Strategy to Improve Hepatic Health Status

A 10-week feeding trial was conducted to investigate the beneficial effects of bile acids (BAs) on hepatic health status in tongue sole ( Cynoglossus semilaevis ). Three experimental diets were prepared with different levels BA inclusion commercial basal diet: control group (CT: 0 mg/kg diet), low-level (BA1: 300 and high-level (900 diet). At end trial, growth performance survival rate measured, as well numerous physiological biochemical parameters liver, including four function indices, five antioxidant lipid metabolism parameters, three digestive enzyme activities. Moreover, mRNA expression growth-related genes immune-related liver assayed. Results showed that substantially improved both low- inclusive groups. Further, tested combined quantitative real-time PCR results revealed enhanced capacity, energy metabolism, ability, immune response. Finally, these findings provide a wider spectrum dietary BAs sole.